Stimulation of the reticuloendothelial system of mice by muramyl dipeptide
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چکیده
منابع مشابه
Stimulation of the reticuloendothelial system of mice by muramyl dipeptide.
Muramyl dipeptide (MDP), a part of bacterial cell wall peptidoglycans, was active as adjuvant and stimulated the reticuloendothelial system (RES) of mice to increase its phagocytic function. A series of analogs of MDP was tested for their adjuvant activity and RES-stimulating activity. Sex differences were observed in the adjuvant activity and RES-stimulating capacity of some MDP analogs. A ste...
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The effect on respiratory burst of murine splenic cells after in vitro exposure to synthetic muramyl dipeptide (MDP) and 6-O-acyl and quinonyl derivatives was studied at an early phase of interaction by luminol-dependent chemiluminescence (CL) in response to stimulation by zymosan. The MDP molecule enhanced CL, but the degree of CL response varied with the kinds of fatty acids introduced in the...
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15 صفحه اولDegradation of muramyl dipeptide by mammalian serum.
Muramyl dipeptide, N-acetylmuramyl-L-alanine-D-isoglutamine (MDP), is the minimal biologically active subunit of bacterial peptidoglycan and elicits an acute inflammation in vivo. We now report that MDP is degraded by normal rat serum into its constituents, N-acetylmuramic acid and L-alanine-D- isoglutamine. The dipeptide is further degraded into its components L-alanine and D-isoglutamine. The...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1979
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.24.2.302-307.1979